Table 1.
Post-vaccination anti-influenza immunity in the mother-infant pairs.
| Group I – Grippol Plus (n = 42) |
Group II – Agrippal S1 (n = 37) |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A/California/7/2009 (H1N1)pdm09-like virus |
A/Perth/16/2009 (H3N2)-like virus |
B/Brisbane/60/2008-like virus |
A/California/7/2009 (H1N1)pdm09-like virus |
A/Perth/16/2009 (H3N2)-like virus |
B/Brisbane/60/2008-like virus |
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| Parameter | Time | Mother | Infant | Mother | Infant | Mother | Infant | Mother | Infant | Mother | Infant | Mother | Infant |
| Seropositivelevel (%) (hemagglutinin inhibition titre ≥ 1:40) | 2–3 daysafter birth | 64.8 | 53.1 | 78.4 | 62.5 | 75.7 | 59.4 | 67.6 | 61.5 | 62.2 | 57.7 | 91.9 ✕ |
80.8 ✕ |
| 3 monthsafter birth | 54.3 | 21.9 **/Δ |
71.4 | 12.5 **/ΔΔ | 74.3 | 15.6 **/ΔΔ | 62.2 | 34.6 **/Δ |
51.4 ✕ |
30.8 ✕/*/Δ |
72.9 | 42.3 ✕/**/Δ |
|
| Geometric mean antibody titre (log2) | 2–3 daysafter birth | 38.19± 0.24 |
25.78± 0.26 |
45.95± 0.25 |
31.74± 0.17 |
54.01± 0.27 |
31.02± 0.19 Δ |
42.38± 0.39 |
37.03± 0.65 |
34.82± 0.68 ✕ |
23.78± 0.40 |
85.74± 0.28 ✕ |
33.64± 0.50 ΔΔ |
| 3 monthsafter birth | 30.31± 0,26 | 12,59± 0.22 **/Δ |
30.31± 0.21 |
14.47± 0.18 **/Δ |
44.89± 0.23 |
13.50± 0.21 **/Δ |
27.32± 0.38 * |
20.00± 0.55 * |
23.78± 0.59 * |
10.91± 0.44 **/Δ |
47.57± 0.45 ** |
18.34± 0.40 **/Δ |
|
Notes:
✕- p < 0.05 – comparing the groups
* – р < 0.05 ** – p < 0.01- for the intra-group changes
Δ – p < 0.05; ΔΔ- p < 0.01 – for mother-infant differences