Table 2.
The 37 pleiotropic genes identified by the metaCCA and VEGAS2 analysis.
| Locus | Gene | MetaCCA adjusted p-value | VEGAS adjusted p-value | ||||
|---|---|---|---|---|---|---|---|
| ADHD | MD | BP | ASD | SCZ | |||
| 1 | SRPK2 | 0 | 0.37 | 0.40 | 0.05 | 0.06 | 1.0E-06 |
| 2 | DPYD | 8.5E-292 | 0.58 | 0.19 | 0.75 | 0.35 | 1.0E-06 |
| 3 | MAD1L1 | 4.0E-120 | 0.66 | 0.92 | 2.1E-04 | 0.03 | 1.0E-06 |
| 4 | F0XP1 | 3.1E-107 | 0.37 | 0.02 | 0.46 | 0.01 | 1.0E-06 |
| 5 | CACNA1C | 1.0E-65 | 0.37 | 0.20 | 1.0E-06 | 0.41 | 1.0E-06 |
| 6 | RGS7 | 2.7E-74 | 0.05 | 0.53 | 0.30 | 0.50 | 1.0E-06 |
| 7 | IMMP2L | 9.5E-63 | 0.35 | 0.08 | 0.21 | 0.81 | 1.0E-06 |
| 8 | SLC8A3 | 9.6E-33 | 0.14 | 0.38 | 0.96 | 0.06 | 1.0E-06 |
| 9 | CEMIP | 1.4E-39 | 0.60 | 0.15 | 1.5E-03 | 0.14 | 1.0E-06 |
| 10 | CACNB2 | 4.0E-47 | 0.07 | 0.02 | 6.1E-03 | 0.46 | 1.0E-06 |
| 11 | SCAPER | 5.2E-28 | 0.31 | 0.54 | 0.11 | 0.33 | 1.0E-06 |
| 12 | ANKRD44 | 4.6E-24 | 0.52 | 0.44 | 0.03 | 0.51 | 1.0E-06 |
| 13 | ISC20 | 1.5E-17 | 1.9E-03 | 0.36 | 0.01 | 0.06 | 1.0E-06 |
| 14 | TMEM120B | 4.8E-13 | 0.12 | 0.21 | 0.44 | 0.15 | 1.0E-06 |
| 15 | ZSWIM6 | 1.2E-15 | 0.04 | 0.24 | 0.04 | 0.05 | 1.0E-06 |
| 16 | TRANK1 | 1.1E-12 | 0.62 | 0.56 | 0.01 | 0.08 | 1.0E-06 |
| 17 | ALPI | 4.2E-11 | 0.43 | 0.03 | 0.03 | 0.13 | 1.0E-06 |
| 18 | EFHD1 | 2.2E-11 | 0.56 | 0.02 | 0.01 | 0.03 | 1.0E-06 |
| 19 | RCOR1 | 3.9E-08 | 0.06 | 0.14 | 0.03 | 0.77 | 1.0E-06 |
| 20 | OPN3 | 1.8E-07 | 0.28 | 0.68 | 0.02 | 0.75 | 1.0E-06 |
| 21 | ITIH4 | 8.8E-10 | 0.02 | 0.06 | 1.4E-04 | 0.10 | 1.0E-06 |
| 22 | LINC01004 | 1.3E-09 | 0.65 | 0.81 | 0.01 | 0.10 | 1.0E-06 |
| 23 | BTN2A1 | 8.1E-11 | 0.85 | 0.34 | 0.01 | 0.91 | 1.0E-06 |
| 24 | GPX6 | 3.1E-09 | 0.19 | 0.10 | 0.04 | 0.39 | 1.0E-06 |
| 25 | ABHD17C | 2.0E-07 | 0.43 | 0.21 | 1.9E-03 | 0.12 | 1.0E-06 |
| 26 | ETF1 | 5.4E-09 | 0.09 | 0.06 | 2.3E-03 | 0.20 | 1.0E-06 |
| 27 | ARFGEF2 | 3.1E-07 | 0.30 | 0.31 | 0.02 | 0.84 | 1.0E-06 |
| 28 | CREB3L1 | 3.2E-07 | 0.15 | 0.76 | 0.47 | 6.3E-04 | 1.0E-06 |
| 29 | KMO | 2.5E-09 | 0.43 | 0.83 | 0.04 | 0.55 | 1.0E-06 |
| 30 | SNAP91 | 1.4E-07 | 0.33 | 0.35 | 2.8E-03 | 1.00 | 1.0E-06 |
| 31 | HIST1H3D | 1.2E-07 | 0.35 | 0.25 | 0.42 | 0.24 | 1.0E-06 |
| 32 | C3orf49 | 1.7E-06 | 0.54 | 0.15 | 0.06 | 0.73 | 1.0E-06 |
| 33 | C2 | 1.6E-07 | 0.83 | 0.11 | 0.01 | 0.63 | 1.0E-06 |
| 34 | ZSCAN23 | 2.3E-06 | 0.36 | 0.08 | 0.03 | 0.23 | 1.0E-06 |
| 35 | ZNF391 | 3.0E-06 | 0.49 | 0.02 | 0.03 | 0.70 | 1.0E-06 |
| 36 | STAB1 | 3.5E-06 | 0.12 | 0.01 | 4.5E-03 | 0.07 | 1.0E-06 |
| 37 | HFE | 2.4E-06 | 0.43 | 0.11 | 0.07 | 0.49 | 1.0E-06 |