Table 3.
The features of 37 significant pleiotropic genes.
| Locus | Gene | Chr | Gene type | r-value | Adjusted p-value | Number of SNPs |
|---|---|---|---|---|---|---|
| 1 | SRPK2 | 7 | Novel | 0.21 | 0 | 5 |
| 2 | DPYD | 1 | Confirmed(Noor et al., 2010; Witt et al., 2017) | 0.15 | 8.5E-292 | 26 |
| 3 | MAD1L1 | 7 | Confirmed(Ruderfer et al., 2014) | 0.10 | 4.0E-120 | 10 |
| 4 | F0XP1 | 3 | Confirmed(Autism Spectrum Disorders Working Group of The Psychiatric and Consortium, 2017; | 0.09 | 3.1E-107 | 25 |
| Nurnberger et al., 2014) | ||||||
| 5 | CACNA1C | 12 | Confirmed(Consortum, 2013; Dedic et al., 2017; Gasso et al., 2016) | 0.08 | 1.0E-65 | 31 |
| 6 | RGS7 | 1 | Novel*(Jayaraman et al., 2009) | 0.08 | 2.7E-74 | 31 |
| 7 | IMMP2L | 7 | Confirmed(Casey et al., 2012; Elia et al., 2010; Goes et al., 2015) | 0.07 | 9.5E-63 | 16 |
| 8 | SLC8A3 | 14 | Novel | 0.06 | 9.6E-33 | 8 |
| 9 | CEMIP | 15 | Novel | 0.06 | 1.4E-39 | 18 |
| 10 | CACNAB2 | 12 | Confirmed(Soldatov, 2015) | 0.06 | 4.0E-47 | 21 |
| 11 | SCAPER | 15 | Novel | 0.06 | 5.2E-28 | 3 |
| 12 | ANKRD44 | 2 | Novel | 0.05 | 4.6E-24 | 10 |
| 13 | ISG20 | 15 | Novel | 0.04 | 1.5E-17 | 3 |
| 14 | TMEM120B | 12 | Novel | 0.04 | 4.8E-13 | 5 |
| 15 | ZSWIM6 | 5 | Novel*(Twigg et al., 2016) | 0.04 | 1.2E-15 | 3 |
| 16 | TRANK1 | 3 | Confirmed(Ruderfer et al., 2014; Schimmelmann et al., 2013) | 0.04 | 1.1E-12 | 4 |
| 17 | ALPI | 2 | Novel | 0.04 | 4.2E-11 | 2 |
| 18 | EFHD1 | 2 | Novel*(Alkelai et al., 2011) | 0.04 | 2.2E-11 | 2 |
| 19 | RCOR1 | 14 | Novel | 0.03 | 3.8E-08 | 4 |
| 20 | OPN3 | 1 | Novel | 0.03 | 1.8E-07 | 2 |
| 21 | TTIH4 | 3 | Confirmed(Cross-Disorder Group of the Psychiatric Genomics Consortum, 2013) | 0.03 | 8.8E-10 | 1 |
| 22 | UNC01004 | 7 | Novel | 0.03 | 1.3E-09 | 1 |
| 23 | BTN2A1 | 6 | Novel | 0.03 | 8.1E-11 | 2 |
| 24 | GPX6 | 6 | Novel | 0.03 | 3.1E-09 | 1 |
| 25 | ABHD17C | 15 | Novel | 0.03 | 2.0E-07 | 2 |
| 26 | ETF1 | 5 | Novel*(Kao et al., 2016) | 0.03 | 5.4E-09 | 1 |
| 27 | ARFGEF2 | 20 | Novel | 0.03 | 3.1E-07 | 2 |
| 28 | CREB3L1 | 11 | Novel | 0.03 | 3.2E-07 | 2 |
| 29 | KMO | 1 | Confirmed(Borsini et al., 2017; Wurfel et al., 2017) | 0.03 | 2.5E-09 | 6 |
| 30 | SNAP91 | 6 | Confirmed(Goes et al., 2012) | 0.03 | 1.4E-07 | 5 |
| 31 | MST1H3D | 6 | Novel | 0.03 | 1.2E-07 | 1 |
| 32 | C3orf49 | 3 | Novel | 0.03 | 1.7E-06 | 2 |
| 33 | C2 | 6 | Confirmed(Cortabitarte et al., 2017; Khoury et al., 2017) | 0.03 | 1.6E-07 | 1 |
| 34 | ZSCAN23 | 6 | Novel | 0.03 | 2.3E-06 | 1 |
| 35 | ZNF391 | 6 | Novel | 0.03 | 3.0E-06 | 1 |
| 36 | STAB1 | 3 | Confirmed(Lee et al., 2013b; Witt et al., 2014) | 0.03 | 3.5E-06 | 1 |
| 37 | HFE | 6 | Confirmed(Buretic-Tomljanovic et al., 2012; Guerini et al., 2009; Nigg et al., 2016) | 0.03 | 2.4E-06 | 4 |
Note:
Confirmed: This gene was previously reported to be associated with more than one psychiatric disorder.
Novel
*
: This gene had been reported to be associated with only one psychiatric disorder.
Novel: This gene had never been reported to be associated with any psychiatric disorder.