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. Author manuscript; available in PMC: 2019 Jan 23.
Published in final edited form as: J Affect Disord. 2018 Jul 17;242:234–243. doi: 10.1016/j.jad.2018.07.046

Table 4.

Top five significant GO term enrichment of the pleiotropic genes.

Term(GO_Cellular_Component) p-value Adjusted p-value Genes
L-type voltage-gated calcium channel complex(GO:1990454) 7.0E-05 1.0E-02 CACNB2;CACNA1C
apical recycling endosome(GO:0090653) 9.2E-03 4.8E-02 AKFGEF2;HFE
basolateral recycling endosome(GO:0090654) 9.2E-03 4.8E-02 AKFGEF2;HFE
recycling endosome(GO:0055037) 9.2E-03 4.8E-02 AKFGEF2;HFE
peri-centrosomal recycling endosome(GO:0098832) 9.2E-03 4.8E-02 ARFGEF2;HFE
Term(GO_Molecular_Function) p-value Adjusted p-value Genes
flavin adenine dinucleotide binding(GO:0050660) 7.5E-04 4.8E-02 DPYD;KMO
FADH2 binding(GO:0071950) 7.5E-04 4.8E-02 DPYD;KMO
voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels(GO:0099511) 1.4E-03 4.8E-02 CACNB2;CACNA1C
intermediate voltage-gated calcium channel activity(GO:1990028) 1.4E-03 4.8E-02 CACNB2;CACNA1C
voltage-gated calcium channel activity involved in cardiac muscle cell action potential (GO:0086007) 1.4E-03 4.8E-02 CACNB2;CACNA1C