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. Author manuscript; available in PMC: 2019 Jan 23.
Published in final edited form as: Nat Chem. 2017 Dec 4;10(2):205–211. doi: 10.1038/nchem.2888

Figure 3: Survey of functional group tolerance for the C-terminal-selective photoredox decarboxylative conjugate addition.

Figure 3:

The scope of decarboxylative functionalization proves quite general with respect to the various functional groups present in the canonical amino acids at physiological pH. Importantly, no reaction was detected at the Asp or Glu site in tetramers containing these competing acid functionalities. Enhanced reactivity is observed using a pH 3.5 buffer. a30 mol% photocatalyst 1b. Yields reported as a % conversion as determined from reverse phase HPLC and are an average of three independent trials.