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Overall eye size in control and mutant mice. Control (A) and mutant (B) eyes shown in vivo before enucleation and preparation. Mutant eyes are clearly protruding and enlarged compared to control eyes. Representative histologic cross-sections of enucleated eyes from 14-day-old (C, D) and adult (14–17.5 months old; E, F) normal (C, E) and mutant eyes (D, F) shows a large difference in the overall eye size between the two groups. Scale bars: C, D, E, and F = 1 mm.
