Figure 4.

RPE ultrastructure in control and mutant mice. Transmission electron micrographs of the outermost retinal layers in control (CTRL, left panel) and mutant mice (KO, right panel) shows no apparent ultrastructural differences in 5-day-old mice (A, B). In contrast, we observed a large number of ultrastructural abnormalities in 14-day-old mutant mice (D) including thinning of the photoreceptor outer segment layer, macromelanosomes, melanolipofuscin-like structures, as well as a loss of basal infoldings. Scale bars: A, B, C, and D = 2 μm.