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. 2019 Jan;60(1):322–330. doi: 10.1167/iovs.18-25667

Figure 6.

Figure 6

RPE cell ultrastructure in control and mutant 14-day-old mice. Transmission electron micrographs of RPE cells from control (A, C, [zoom of region in A] and D) and mutant (B, E, F, G) 14-day-old mice illustrating the ultrastructural abnormalities identified in mutant mice including loss of basal infoldings (B), large melanolipofuscin-like structures (B, E), distended and fragmented endoplasmic reticulum throughout the cytoplasm (B, F, G), scattered and detached ribosomes (example indicated by small black box [F, G]), apparent increased number of Golgi apparatus (G) as well as a general absence of clathrin-coated vesicles (B, F, G). BI, basal infoldings; BM, basal membrane; ccv, clathrin-coated vesicles; dER, dilated endoplasmic reticulum; G, Golgi apparatus; M, melanosome; Mit, mitochondrion; ML, melanolipofuscin-like; POS, photoreceptor outer segment; Pr, polyribosome. Scale bars: A, B, G = 1 μm, C, D = 500 nm; E, F = 200 nm.