Table 1.

Tumor volume changes in each group at 7d, 14d and 21d.

Groups	Tumor size (mm3)
	7d	14d	21d
TMZ+AAV2-VEGF-Trap	15.31 ± 2.45	34.11 ± 3.43**	79.31 ± 4.05**
TMZ+BEV	16.48 ± 3.28	34.09 ± 3.42**	76.37 ± 4.03**
TMZ	16.40 ± 1.73	46.82 ± 3.53*	93.86 ± 1.85*
AAV2-VEGF-Trap	15.53 ± 2.42	46.51 ± 2.75*	94.17 ± 3.61*
BEV	14.99 ± 2.88	46.82 ± 3.08*	94.02 ± 1.07*
Control	15.78 ± 3.58	57.55 ± 2.52	104.73 ± 0.72

Abbreviations: TMZ, temozolomide; AAV2-VEGF-Trap, adeno-associated virus 2 mediated gene transfer of vascular endothelial growth factor Trap; BEV, bevacizumab.

P values:

**: TMZ+AAV2-VEGF-Trap group and TMZ+BEV group vs. TMZ group, AAV2-VEGF-Trap group, BEV group and control group, ＜0.01;

*: TMZ group, AAV2-VEGF-Trap group and BEV group vs. control group, ＜0.05.