Figure 2.

Dynamic features of dual-phase p53 under stimulation by different Dox dosage. (a) Selected total p53 trajectories when Dox = 0.01, 0.1 and 10. Note that the unit of ‘p53 levels’ in stochastic simulation is 1. (b) Fraction of terminal pulses at different Dox levels. (c) Comparison of effective p53 integral between survival and apoptotic cells. The unit for effective p53 integral during stochastic simulation is ‘min’ thereafter. (d-e) Lifespan (d) and terminal pulse height (e) treated by relatively low levels (0.01, 0.05 and 0.1) of Dox. Data were represented as mean±SD. (f) Effective p53 integral of apoptotic cells under different Dox levels. (g) Pulse height (top) and duration (bottom) for cells with Dox = 0.01, 0.05 and 0.1.