Table 1.
PERCENTAGE OF SURVIVAL AT A GIVEN TIMEPOINT |
SCORE AT A GIVEN TIMEPOINT |
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PATHWAY | Number of involved genes | 1 H | 2 H | 4 H | 6 H | 1 H | 2 H | 4 H | 6 H |
APOPOTOSIS & CELL DEATH | 626 | 4.95 | 2.56 | 5.11 | 3.51 | 10 | 2 | 11 | 9 |
OXIDATIVE STRESS | 387 | 4.39 | 3.10 | 4.91 | 3.62 | 9 | 5 | 10 | 10 |
FATTY ACIDS METABOLISM | 1047 | 3.92 | 3.92 | 3.92 | 4.68 | 6 | 11 | 3 | 12 |
PHOTOTRANSDUCTION | 659 | 3.64 | 2.58 | 4.25 | 2.12 | 3 | 3 | 6 | 3 |
SIGNAL TRANSDUCTION | 2057 | 3.94 | 3.31 | 4.08 | 3.31 | 7 | 6 | 5 | 8 |
CYTOSKELETON AND TRAFFICKING | 2164 | 3.84 | 3.56 | 4.62 | 3.19 | 4 | 10 | 9 | 6 |
RNA PROCESSING | 296 | 5.74 | 4.39 | 6.42 | 4.39 | 13 | 13 | 13 | 11 |
SPLICING | 200 | 3.00 | 2.50 | 2.50 | 2.00 | 2 | 1 | 2 | 2 |
PROTEOSTASIS | 1600 | 3.88 | 3.50 | 4.25 | 3.25 | 5 | 9 | 7 | 7 |
MITOCHONDRION | 686 | 5.39 | 4.81 | 6.56 | 5.39 | 11 | 14 | 14 | 13 |
INFLAMMATION | 269 | 5.95 | 3.35 | 4.46 | 6.32 | 14 | 7 | 8 | 14 |
NEURON | 622 | 2.73 | 2.89 | 4.02 | 2.73 | 1 | 4 | 4 | 4 |
EPIGENETIC | 526 | 5.51 | 3.42 | 5.32 | 2.85 | 12 | 8 | 12 | 5 |
CIRCADIAN RHYTHMS | 76 | 3.95 | 3.95 | 1.32 | 1.32 | 8 | 12 | 1 | 1 |
In Table 1 are reported the 14 “macro-pathways”, showed the highest number of genes with the highest alteration of expression, classified by selection of 5271 genes together with the percentage of survived genes at each time point as well as the obtained score, based on its ranking.