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. 2018 Sep 27;20(1):21–30. doi: 10.1080/15384047.2018.1504718

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© 2018 The Author(s). Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — PF384 and PD901 in combination induces apoptosis in PDAC cell lines. a) BxPC-3, MIA-Pa-Ca-2, b) Panc-1 and Panc05.04 cells were treated as indicated for 24 hours after which fold-apoptosis was determined as caspase-3/7 activity normalised to MTT cell viability data. All data shown are the mean ± SEM for 3 independent experiments. *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001, one-way ANOVA. CI < 1.

Inline graphic — PF384 and PD901 in combination induces apoptosis in PDAC cell lines. a) BxPC-3, MIA-Pa-Ca-2, b) Panc-1 and Panc05.04 cells were treated as indicated for 24 hours after which fold-apoptosis was determined as caspase-3/7 activity normalised to MTT cell viability data. All data shown are the mean ± SEM for 3 independent experiments. *p ≤ 0.05, **p ≤ 0.01, ****p ≤ 0.0001, one-way ANOVA. CI < 1.