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. 2018 Sep 27;20(1):21–30. doi: 10.1080/15384047.2018.1504718

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© 2018 The Author(s). Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — PDCD4 expression decreases in response to PF384/PD901 treatment, and siRNA-mediated silencing identifies a role for it in apoptosis induced by this combination. a) BxPC3, MIA-PaCa-2 and PEA2 cells were treated as indicated for 6 hours after which whole cell lysates were processed for RPPA analysis, and normalised Log2 median-centred values used to calculate relative expression of PDCD4. b) MIA-PaCa-2 cells were transfected with NTC or PDCD4 siRNA, or mock transfected for 48 hours, after which they were re-seeded and treated as indicated for 24 hours. Fold-apoptosis was determined as caspase-3/7 activity normalised to MTT cell viability data. All data shown are the mean ± SEM for 3 independent experiments. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001, one-way ANOVA.