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. 2018 Dec 27;17(24):2745–2755. doi: 10.1080/15384101.2018.1556060

Figure 4.

Figure 4.

Knockdown of Wnt2 reversed the effect of miR-221 inhibitor on the proliferation and apoptosis of hippocampal neurons. Hippocampal neurons were divided into NC group, miR-221 inhibitor group, miR-221 inhibitor+si-NC group, and miR-221 inhibitor+si-Wnt2 group. (a) The proliferation of hippocampal neuronal. (b) The apoptosis of hippocampal neuronal. (c) The protein expression of Wnt2, p-CREB and BDNF. **P < 0.01 vs NC, ##P < 0.01 vs miR-221 inhibitor+ si-NC. Hippocampal neurons were divided into NC group, miR-221 mimic group, miR-221 mimic+Lenti-NC group, and miR-221 mimic+Lenti-Wnt2 group. (d) The proliferation of hippocampal neuronal. (e) The apoptosis of hippocampal neuronal. (f) The protein expression of Wnt2, p-CREB and BDNF. **P < 0.01 vs NC, ##P < 0.01 vs miR-221 mimic+Lenti-NC.