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Overexpression miR-221 reversed the treatment of fluoxetine on CUMS mice. Mice were divided into 3 groups, including CUMS group, CUMS+fluoxetine group, and CUMS+fluoxetine+miR-221 agomir group. MiR-221 agomir was used to up-regulate miR-221 expression. (a) SPT. (b) FST. (c) TST. (d) The content of CORT. (e) miR-221 expression. (f) The protein expression of Wnt2, p-CREB and BDNF. **P < 0.01 vs CUMS, ##P < 0.01 vs CUMS+ fluoxetine.
