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The glycolysis-dependent MEC1 cell line is susceptible to 2DG in vivo. (A) Metabolic comparison of two AID-positive B-cell lines, MEC1 and CCRF-SB with (B) similar growth rates ex vivo (N = 3 in two experiments). (C) Graphs showing bone marrow and spleen tumor burden as measured by human CD19+ cells (N = 4 mice). (D) Comparison of free glucose inside spleen and bone marrow cells of mice treated with 2DG or Glucose (6 g/L) or regular water (vehicle) for 1 week (N = 5 Mice per group).
