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. 2018 Dec 27;18(2):156–166. doi: 10.1080/15384101.2018.1560202

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Figure 5. — LncRNA MIAT overexpression reduced neuron apoptosis through miR-211. Neuro2A cells were transfected with pcDNA-MIAT or miR-211 mimic. After the treatment of OGD (3 h)/reoxygenation (24 h), Neuro2A cells were divided into Normoxia, OGD/reoxygenation, OGD/reoxygenation+pcDNA, OGD/reoxygenation+pcDNA-MIAT, OGD/reoxygenation+pcDNA-MIAT+pre-NC, OGD/reoxygenation+pcDNA-MIAT+miR-211 mimic groups. (a) Under the treatment of OGD/reoxygenation, pcDNA-MIAT downregulated miR-211 expression, and miR-211 mimic abolished the inhibition effect of pcDNA-MIAT. (b) pcDNA-MIAT increased GDNF expression, and miR-211 mimic abolished the promotion effect of pcDNA-MIAT. (c) pcDNA-MIAT reduced the apoptosis of Neuro2A cells, and miR-211 mimic abolished the inhibition effect of pcDNA-MIAT. (d) pcDNA-MIAT downregulated the expression of caspase-3, and miR-211 mimic abolished the inhibition effect of pcDNA-MIAT. *p < 0.05, compared with normoxia; #p < 0.05, compared with OGD/reoxygenation+pcDNA; &p < 0.05, compared with OGD/reoxygenation+pcDNA-MIAT+pre-NC.