. 2018 Dec 31;22(4):39–54. doi: 10.20463/jenb.2018.0029

Table 10. Changes in the hepatic glucose-regulating enzyme activities in NFD or HFD-fed mice.

Items	Glucokinase (nM/min/mg protein)	Glucose-6-phosphatase (nM/min/mg protein)	PEPCK (nM/min/mg protein)
Groups	Glucokinase (nM/min/mg protein)	Glucose-6-phosphatase (nM/min/mg protein)	PEPCK (nM/min/mg protein)
Controls
Intact	5.88±1.63	121.38±31.97	2.08±1.15
HFD	0.94±0.48^d	387.30±83.00^d	7.98±1.21^a
Reference
Metformin	2.08±0.49^d^f	211.27±29.00^d^f	4.63±1.26^a^c
Test material - BH
400 mg/kg	3.07±0.65^d^f	158.96±25.68^e^f	3.35±0.54^b^c
200 mg/kg	2.07±0.55^d^f	210.00±40.65^d^f	4.46±0.60^a^c
100 mg/kg	1.56±0.26^d^g	256.57±38.10^d^f	5.21±0.96^a^c

Values are expressed as Mean ± SD of 8 mice

NFD = Normal pellet diet; HFD = 45% kcal high fat diet; PEPCK = Phosphoenolpyruvate carboxykinase

BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts

Metformin was administrated at a dose level of 250 mg/kg

^a p<0.01 and ^b p<0.05 as compared with the intact control group at time-matched point by LSD test

^c p<0.01 as compared with the HFD control group at time-matched point by LSD test

^d p<0.01 and ^e p<0.05 as compared with the intact control group at time-matched point by MW test

^f p<0.01 and ^g p<0.05 as compared with the HFD control group at time-matched point by MW test