. 2018 Dec 31;22(4):39–54. doi: 10.20463/jenb.2018.0029

Table 2. Changes in body weight gain and mean daily food consumption in NFD or HFD-fed mice.

Times	Body weight (g) at days after initial test substance treatment				Body weight gain during		Mean Daily Food Consumption (g)
Groups	8 days before [A]	1 day before [B]	0 day^* [C]	84 days^* [D]	Adaptive period [B-A]	Administration period [D-C]	Mean Daily Food Consumption (g)
Controls
Intact	30.48±1.49	30.88±1.55	27.86±1.48	33.45±1.69	0.45±0.20	5.59±0.83	5.58±0.29
HFD	30.46±1.03	34.75±1.04^a	31.79±0.92^a	50.18±1.73^a	4.29±0.25^a	18.39±1.48^a	4.65±0.23^a
Reference
Metformin	30.40±1.35	34.78±1.26^a	31.95±1.24^a	43.71±1.25^a^b	4.38±0.20^a	11.76±0.97^a^b	4.71±0.20^a
Test material - BH
400 mg/kg	30.49±1.49	34.70±1.38^a	31.71±1.84^a	40.35±2.18^a^b	4.21±0.17^a	8.64±0.85^a^b	4.67±0.18^a
200 mg/kg	30.45±1.50	34.74±1.82^a	31.83±1.47^a	43.41±2.20^a^b	4.29±0.17^a	11.59±1.59^a^b	4.67±0.22^a
100 mg/kg	30.45±1.31	34.68±1.19^a	31.94±1.71^a	45.70±2.37^a^b	4.23±0.31^a	13.76±1.22^a^b	4.65±0.22^a

Values are expressed as Mean ± SD of 8 mice

NFD = Normal pellet diet; HFD = 45% kcal high fat diet

BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts

Metformin was administered at a dose of 250 mg/kg

* All animals were fasted overnight

^a p<0.01 as compared with the intact control group at time-matched point by LSD test

^b p<0.01 as compared with the HFD control group at time-matched point by LSD test