. 2018 Dec 31;22(4):39–54. doi: 10.20463/jenb.2018.0029

Table 4. Changes in Serum AST, ALT, ALP, LDH, GGT, BUN and Creatine levels in NFD or HFD-fed mice.

Items	AST (IU/l)	ALT (IU/l)	ALP (IU/l)	LDH (IU/l)	GGT (IU/l)	BUN (mg/dl)	Creatinine (mg/dl)
Groups	AST (IU/l)	ALT (IU/l)	ALP (IU/l)	LDH (IU/l)	GGT (IU/l)	BUN (mg/dl)	Creatinine (mg/dl)
Controls
Intact	58.63±14.69	33.50±11.64	88.63±20.37	298.25±125.20	1.75±0.71	33.13±10.36	0.64±0.30
HFD	185.13±25.77^a	146.25±24.07^a	219.38±31.95^a	2139.50±376.26^a	10.63±1.60^a	99.38±15.90^a	2.38±0.41^d
Reference
Metformin	128.63±20.63^a^c	99.00±15.45^a^c	150.75±26.08^a^c	1466.13±233.26^a^c	6.88±1.25^a^c	66.50±12.55^a^c	1.60±0.14^d^e
Test material – BH
400 mg/kg	80.50±11.95^b^c	66.38±14.89^a^c	109.00±14.96^c	990.88±159.80^a^c	4.75±1.39^a^c	47.13±10.80^b^c	1.14±0.22^d^e
200 mg/kg	127.00±14.67^a^c	98.75±10.94^a^c	145.75±23.85^a^c	1439.50±252.60^a^c	7.00±1.20^a^c	66.63±12.18^a^c	1.61±0.27^d^e
100 mg/kg	146.13±10.53^a^c	113.25±17.41^a^c	173.38±16.65^a^c	1652.50±228.50^a^c	7.88±1.36^a^c	76.13±9.31^a^c	1.88±0.16^d^e

Values are expressed as Mean ± SD of 8 mice

NFD = Normal pellet diet; HFD = 45% kcal high fat diet; ALT = Alanine aminotransferase; AST = Aspartate aminotransferase; ALP = Alkaline phosphatase; LDH = Lactate dehydrogenase; GGT = Gamma-glutamyltransferase; BUN = Blood urea nitrogen

BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts

Metformin was administrated at a dose level of 250 mg/kg

^a p<0.01 and ^b p<0.05 as compared with the intact control group at time-matched point by LSD test

^c p<0.01 as compared with the HFD control group at time-matched point by LSD test

^d p<0.01 as compared with the intact control group at time-matched point by MW test

^e p<0.01 as compared with the HFD control group at time-matched point by MW test