Table 6. Changes in the liver lipid peroxidation and antioxidant defense systems in NFD or HFD-fed mice.
| Items | Lipid peroxidation | Antioxidant defense system | ||
|---|---|---|---|---|
| Groups | Malondialdehyde (nM/mg tissue) |
Glutathione (μM/mg tissue) |
Catalase (U/mg tissue) |
SOD (U/mg tissue) |
| Controls | ||||
| Intact | 6.08±1.91 | 69.95±13.05 | 67.48±18.37 | 7.57±1.05 |
| HFD | 76.25±10.33d | 11.48±3.76a | 11.34±2.97d | 1.24±0.47a |
| Reference | ||||
| Metformin | 50.95±10.97de | 30.19±10.65ab | 31.51±13.58de | 3.39±0.97ab |
| Test material - BH | ||||
| 400 mg/kg | 31.55±10.98de | 50.39±10.79ab | 48.15±12.16e | 5.03±1.37ab |
| 200 mg/kg | 49.98±12.40de | 31.77±11.17ab | 31.34±8.02de | 3.43±0.65ab |
| 100 mg/kg | 58.53±12.66de | 24.56±9.04ac | 23.36±8.84de | 2.57±0.97ab |
Values are expressed as Mean ± SD of 8 mice
NFD = Normal pellet diet; HFD = 45% kcal high fat diet; SOD = Superoxide dismutase
BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts
Metformin was administrated at a dose level of 250 mg/kg
a p<0.01 as compared with the intact control group at time-matched point by LSD test
b p<0.01 and c p<0.05 as compared with the HFD control group at time-matched point by LSD test
e p<0.01 as compared with the HFD control group at time-matched point by MW test
d p<0.01 as compared with the intact control group at time-matched point by MW test