Table 7. Changes in the histopathology-histomorphometry of the periovarian and abdominal wall deposited fat pads in NFD or HFD-fed mice.

Items	Lipid peroxidation	Antioxidant defense system
Groups	Thickness (mm)	Adipocyte diameters (μm)	Thickness (mm)	Adipocyte diameters (μm)
Controls
Intact	1.27±0.48	33.23±5.80	1.61±0.77	36.12±3.86
HFD	4.53±0.77a	101.82±13.22c	5.92±0.60a	110.08±9.07a
Reference
Metformin	3.14±0.64ab	60.14±7.07cd	4.52±0.56ab	76.30±16.79ab
Test material - BH
400 mg/kg	2.63±0.47ab	48.82±7.52cd	3.83±0.73ab	60.45±11.41ab
200 mg/kg	3.12±0.47ab	59.03±7.35cd	4.53±0.51ab	73.91±8.46ab
100 mg/kg	3.50±0.56ab	73.55±4.10cd	4.75±0.79ab	88.26±8.06ab

Values are expressed as Mean ± SD of 8 mice

NFD = Normal pellet diet; HFD = 45% kcal high fat diet

BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts

Metformin was administrated at a dose level of 250 mg/kg

^a p<0.01 as compared with the intact control group at time-matched point by LSD test

^b p<0.01 as compared with the HFD control group at time-matched point by LSD test

^c p<0.01 as compared with the intact control group at time-matched point by MW test

^d p<0.01 as compared with the HFD control group at time-matched point by MW test