. 2018 Dec 31;22(4):39–54. doi: 10.20463/jenb.2018.0029

Table 9. Changes in histopathology-histomorphometry of the liver and kidney in NFD or HFD-fed mice.

Items	Liver steatosis (%/mm2 of hepatic tissues)	Mean hepatocyte diameters (μm/cell)	Degenerative renal tubule numbers (%)
Groups	Liver steatosis (%/mm2 of hepatic tissues)	Mean hepatocyte diameters (μm/cell)	Degenerative renal tubule numbers (%)
Controls
Intact	9.80±4.57	17.33±2.11	4.50±2.20
HFD	80.05±10.65^a	33.56±2.05^a	73.50±11.84^a
Reference
Metformin	53.66±13.38^a^b	26.13±2.62^a^b	48.38±11.25^a^b
Test material - BH
400 mg/kg	34.57±10.38^a^b	23.58±2.13^a^b	30.00±11.11^a^b
200 mg/kg	53.94±10.77^a^b	26.02±1.44^a^b	48.13±14.47^a^b
100 mg/kg	62.86±10.58^a^b	28.37±1.98^a^b	57.00±10.34^a^b

Values are expressed as Mean ± SD of 8 mice

NFD = Normal pellet diet; HFD = 45% kcal high fat diet

BH extract = Domestic blue honeysuckle (Berries of Lonicera caerulea L.) extracts

Metformin was administrated at a dose level of 250 mg/kg

^a p<0.01 as compared with the intact control group at time-matched point by LSD test

^b p<0.01 as compared with the HFD control group at time-matched point by LSD test