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. 2018 Dec 22;11(1):106–115. doi: 10.1080/19420862.2018.1525253

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LCC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — Protein sequence map of intact IgG1 showing bond cleavages and disulfide bonds. Intact IgG1 at 51+ was isolated in a 50 m/z window for MS/MS analysis. The bond cleavages shown in protein sequence map are the results from combining two ECD and one CAD analysis. Intermolecular and intramolecular disulfide bonds are shown as purple lines. Cysteines connected by disulfide bonds are highlighted in green. The pyroglutamate on Lc and glycosylation site Asn301 on Hc are highlighted in red.