Table 6.
Overall geometric mean relative potency estimates for TNF neutralisation and binding assays.
| Method | Sample | Potencies relative to Candidate A |
Potencies relative to participants IH reference |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GM | LCL | UCL | GCV | n | GM | LCL | UCL | GCV | n | ||
| Neutralisation (all) | A | 1.02 | 0.99 | 1.06 | 5.9% | 16 | |||||
| B | 0.95 | 0.94 | 0.96 | 2.7% | 22 | 0.98 | 0.96 | 1.01 | 5.1% | 16 | |
| C | 1.01 | 1.00 | 1.03 | 3.9% | 21 | 1.03 | 1.00 | 1.07 | 6.5% | 17 | |
| Binding | A | 1.09 | 0.83 | 1.43 | 18.6% | 4 | |||||
| B | 0.95 | 0.86 | 1.05 | 10.4% | 6 | 1.00 | 0.78 | 1.29 | 17.1% | 4 | |
| C | 1.00 | 0.91 | 1.09 | 8.6% | 6 | 1.06 | 0.88 | 1.28 | 12.5% | 4 | |
GM: Geometric Mean; LCL and UCL: Lower and Upper 95% Confidence Limits;
GCV: Inter-laboratory Geometric Coefficient of Variation (%); n: Number of laboratories used in calculation of GM and GCV; IH: In-house reference