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. 2018 Nov 20;8(2):e1539613. doi: 10.1080/2162402X.2018.1539613

Figure 2.

Figure 2.

Inhibition of TGF-β signaling and EOC cell invasion by Fab 5775.

a) The effects of Fab 5775 on TGFβ1-induced SMAD2/3 phosphorylation (pSMAD2/3) was tested at the indicated doses in human SKOV3 and mouse ID8/Trp53−/- cells by IB with pSMAD2/3 and pan reactive SMAD2/3 antibodies. b) Graph depicts the kinetics of SKOV3 cell invasion over 48 hours in media with or without TGFβ1 (10 ng/ml), TGFβ1 + SB431542 (SB, 1 µM) or TGFβ1 + Fab 5775 (1 µM) using an IncuCyte ZOOM system. c) Graph depicts quantification of relative cell invasion for each treatment group described above at the assay endpoint (* p < 0.05, ** p < 0.01).