Figure 5.

Effects of TGFBR2 blockade in metastatic EOC xenograft mouse model.

a) Schematic of metastatic EOC xenograft model involving intraperitoneal (i.p.) injection of SKOV3-Luc cells in female Rag2^−/-:IL2Rɣc^−/- mice. After 3 weeks, mice were randomized between control IgG or 8311 IgG (1 mg/kg, i.p., twice weekly) treatments alone, or in combination with carboplatin (Carbo, 15 mg/kg, i.p., weekly) and treated for 5 weeks. b) Biophotonic imaging of D-luciferin-injected mice was performed, with graph depicting the total photon flux for each mouse and treatment group. c) The tumor nodules were collected and total mass recorded for each mouse and treatment group (* p < 0.05). D) Volcano plot depicts differentially expressed genes in tumors from the 8311 IgG treatment compared to control (n = 3/group) using Nanostring.