Table 1.

Affinities of lead inhibitory antibodies for human and mouse TGFBR2.

IgG clones	KD (M) for human TGFBR2-Fc*	KD (M) for mouse TGFBR2-Fc*
5775	1.68 x10−10	7.30 x10−10
8311	5.30 x10−12	1.18 x10−10
8322	8.34 x10−11	4.95 x10−10
8326	3.95 x10−11	2.12 x10−10
8293	6.34 x10−12	1.38 x10−10

Affinity constants were calculated from SPR experiments testing binding of the indicated IgG clones to human or mouse TGFBR2 ECD constructs fused to hIgG1 Fc domain.