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The N-glycan from both chains exhibit different dynamic behavior upon Aβ or FcγRI binding, indicating the importance of the N-glycan in allosteric signal transduction. (a) The distance between the C1 atom of (α1-6Man-linked) Gal and the Cα atom of proline 458 (left) and proline 1119 (right) are colored by blue and green, respectively. (b) Contact map between N-glycans and the D2 domain of FcγRI in the complex with and without Aβ binding.
