Figure 5.

Downregulation of IL12-mediated signal events is associated with worse clinical outcome. (a) T cell signature enrichment of peritumor-derived CD8⁺ T cells (green) and CD8⁺ TILs cells (red) from each patient using expression profiles of bulk cells. (b) Correlation of IL-12 signature enrichment between CD8⁺ T cells and corresponding bulk cells. P value and coefficient of correlation were calculated using spearman’s rank correlation. (c) Scatter plot of T cell signature enrichment of TCGA samples included in survival analysis (N = 124). (d) Expression levels of IL-12 signature in HCC tissues and paired peritumor tissues from TCGA data set (N = 50). P values were evaluated by Wilcoxon matched-pairs singed rank test. (e) Kaplan–Meier plot of HCC patients stratified by IL-12 signature expression levels (N = 124). Patients expressing higher levels (higher than 75th percentile) of IL-12 signature had better disease-free survival than other patients (log-rank P = 0.021).