Extended Data Figure 10. Example of significant change in observed correlation by addition of few sensitive cell lines:

For Lapatinib sensitivity data, there are 86 overlapping cell lines between CCLE and GDSC datasets. Left panel is an excerpt from Haibe-Kains et al.⁷ Figure 2 comparing the sensitivity data to Lapatinib for the two datasets. Right panel shows the two sensitive cell lines (BT-474 and NCI-H1648) that were missed in Haibe-Kains et al.⁷ analysis. The inclusion of these two cell lines drastically changes the observed Pearson correlation (from 0.25 to 0.53). This is consistent with the simulation results (Extended Data Figure 4B) that show high variability in the observed Pearson correlation for low sample numbers.