Extended data Figure 1. Comparison of pharmacologic data from the CCLE and GDSC studies.

Scatter plots (blue dots) represent the drug sensitivity measured as the Area Under the dose-response Curve (a) and IC50 (b) in overlapping cell lines between CCLE and GDSC studies. For this analysis, IC50 values for insensitive compounds were set to the highest concentration tested in both datasets. The number of overlapping cell lines n for each drug is indicated, as well as the Pearson correlation coefficient R and p-value. In this representation, lower values denote insensitive cell lines. The full distribution of sensitivity values for each drug and study is depicted as ‘violin plots’ (green: CCLE; purple: GDSC) and accounts for all tested cell lines, as opposed to the overlapping set; the grey dot represents the median, thick black line represents the first to third quartile range, and shape of the plot represents the kernel density of the distribution.