Figure 2. Time to colonoscopy after a positive FIT and adjusted risk^a of CRC outcomes (panel A and B).

Abbreviations: Adv-stage, advanced-stage; CI, confidence interval; CRC, colorectal cancer; FIT, fecal immunochemical test. ^aAdjusted for sex; age; race/ethnicity; body mass index; region; FIT screening year; completion of previous FIT screening (ever and in the prior year); and in the year prior to FIT screening, receipt of the flu or pneumonia vaccine, presence of gastrointestinal symptoms (bleeding or blood in stool, unexplained weight loss, abdominal pain, diarrhea, diverticulitis, inflammatory bowel disease, or Lynch syndrome), diagnosis of iron-deficiency anemia or diabetes, current smoker, number of primary care visits, and number of days hospitalized. Models for any CRC include the entire population. Models for advanced adenoma exclude 2,191 patients diagnosed with CRC. Models for advanced-stage CRC exclude 14 patients with CRC of unknown stage. Models for stage-specific CRC exclude patients with CRC of any stage other than the specified stage. The adjusted advanced-stage CRC model dropped 244 patients with unknown BMI because no patient with unknown BMI had this outcome. The adjusted models for CRC stages 0, III, and IV dropped 242 patients with unknown BMI because no patient with unknown BMI had these outcomes. The adjusted CRC stage IV model dropped 2435 patients with unknown race/ethnicity because no patient with unknown race/ethnicity had this outcome.