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. 2019 Jan 23;14(1):e0210275. doi: 10.1371/journal.pone.0210275

Table 3. Subjective feelings of endurance and exertion (1–10 point scales) after a graded exercise test, and perceived muscle power after a 15-s Wingate test with the administration of 3 mg/kg/day of caffeine or a placebo for 20 consecutive days.

Perceived endurance Perceived exertion Perceived muscle power
Day Placebo Caffeine Effect size
(±90% CI)
Qualitative
inference
Placebo Caffeine Effect size
(±90% CI)
Qualitative
inference
Placebo Caffeine Effect size
(±90% CI)
Qualitative
inference
0 5.6±1.2 5.4±0.9 -0.1(-0.6–0.4) Unclear 9.2±1.0 9.5±0.6 0.3(0–0.6) Likely positive 5.4±1.0 5.8±0.7 0.4(-0.1–0.9) Possibly positive
1 5.3±1.5 6.1±0.9* 0.5(0.1–1.0) Likely positive 9.4±1.1 9.4±0.8 -0.1(-0.4–0.3) Unclear 5.7±1.6 6.4±0.7 0.3(-0.2–0.8) Possibly positive
4 5.7±1.1 5.9±1.0 0.2(-0.3–0.8) Unclear 9.4±0.8 9.5±0.7 0.1(-0.5–0.7) Unclear 6.0±0.7 6.2±1.1 0.0(-0.8–0.9) Unclear
6 5.9±0.9 5.8±0.9 -0.1(-0.4–0.3) Unclear 9.5±0.7 9.6±0.7 0.1(-0.1–0.3) Unlikely positive 6.3±0.6 5.7±1.3 -1.0(-2.2–0.2) Unclear
8 5.3±1.5 5.5±1.8 0.1(-0.5–0.7) Unclear 9.5±0.8 9.6±0.5 0.1(-0.3–0.5) Possibly negative 5.0±1.5 5.1±1.7 0.1(-0.5–0.7) Unclear
11 6.1±1.0 5.0±1.8 -1.3(-3.0–0.3) Unclear 9.5±1.0 9.3±1.0 -0.2(-1-0.6) Unclear 6.3±1.3 5.0±1.7 -1.0(-2.3–0.2) Unclear
13 5.5±1.4 6.3±0.8* 0.5(0.1–0.9) Likely positive 9.7±0.5 9.6±0.7 -0.2(-1.0–0.6) Unclear 6.2±1.2 6.2±1.5 -0.1(-0.9–0.7) Unclear
15 5.8±1.5 6.2±0.9 0.2(0.3–0.8) Unclear 9.6±0.7 9.7±0.5 0.0(-0.6–0.6) Unclear 5.8±1.2 5.8±1.4 0.0(-0.8–0.8) Unclear
18 5.8±1.0 6.1±0.9 0.3(-0.2–0.8) Possibly positive 9.8±0.4 9.6±0.9 0.0(-0.4–0.3) Unclear 5.9±1.2 6.1±1.1 0.2(-0.4–0.7) Unclear
20 5.8±1.2 5.6±1.6 -0.1(-0.7–0.4) Unclear 9.8±0.4 9.6±0.9 -0.2(1.5–1.0) Unclear 5.7±0.0 6.3±0.9 0.6(-0.0–1.2) Likely positive

Note: All variables were assessed with 1–10 point scales where 1 point meant minimal amount of the variable and 10 points meant maximal amount of that variable (5 points was the value used to indicate not feeling any difference from a regular day). CI = confidence interval;

(*) Caffeine different from placebo for the same day, P < 0.05.

(†) Different from day “0” within the same treatment, P < 0.05.

Note: On days “0” and “11”, both the placebo and caffeine trials were performed without the administration of any capsule.