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. 2019 Jan 23;14(1):e0209748. doi: 10.1371/journal.pone.0209748

Fig 7. In vivo effect of GLB analog G2 on hepatic ATZ load (A) and hepatic fibrosis (B) in the PiZ mouse model.

Fig 7

The drug was administered by orogastric gavage or subcutaneous osmotic pump predicted to deliver a dose of 10 mg/kg/day over 3 weeks to male PiZ mice at 4–6 months of age. A separate group of age-matched male PiZ littermates were treated with placebo by the same route of administration. Examples of PAS/D and Sirius red staining for livers from 2 untreated (left) and G2 treated mice (right) are shown in (A) and (B), respectively. Results of quantitative morphometric analysis from 4 separate experiments for PAS/D (n = 17, p = 0.0156) are shown on the right in (A). Results of quantitative morphometric analysis from 4 separate experiments for Sirius red (n = 23, p<0.0001) are shown on the right in (B). Results of hydroxyproline content analysis for 1 experiment (n = 7, p = 0.0397) is shown on the far right in (B). Statistical analysis used Unpaired, two-tailed Student t-test for PAS/D staining and hydroxyproline content and unpaired, two-tailed Student t-test with Welch-correction for the Sirius red staining data.