Fig 4. Fungal virulence in a mouse model of disseminated candidiasis.
Eight-week-old female BALB/c mice were intravenously inoculated with 8 × 107 cells of each C. glabrata strain (wild-type, n = 7; Δvph2, n = 9; and Δvph2 + VPH2, n = 8; per experiment). The mice were sacrificed 7 d after inoculation and CFUs per organ in specific organs were determined. The geometric mean is shown as a bar. Data representative of two independent experiments are shown. The C. glabrata strains used were: wild-type (CBS138), filled circles; Δvph2 mutant, squares; and VPH2-reconstituted strain, triangles. *P < 0.05, **P < 0.01, ***P < 0.001 (Kruskal-Wallis test with Dunn’s post-test).