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. 2018 Oct 16;160(2):463–485. doi: 10.1097/j.pain.0000000000001416

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Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Expression patterns of LncRNAs in the mouse DRG. (A and B) Expression plot of annotated ENSEMBL antisense LncRNAs in the BALB/c mouse (A) and B10.D2 mouse (B). (C and D) Novel antisense LncRNAs vs the sense protein-coding gene in BALB/c (C) and B10.D2 (D) strains. Novel LncRNAs antisense to DE genes Inpp1, Epyc, Kcnmb1, Nefl, Nalcn, Nbea, Ttc39aos1, Cgref1, and Zyg11b are significantly DE. (E) Heatmap of novel and annotated intergenic LncRNAs DE between SNT and Sham-operated animals. (F) Hierarchical samples' clustering based on the expression of ENSEMBL annotated and novel LncRNAs in mice. Counts were transformed using the regularized log2 transformation; Euclidean distance was used as a dissimilarity measure and complete linkage was used for clustering. Male samples are in blue and female in pink colour. DE, differentially expressed; DRG, dorsal root ganglion; LncRNAs, long noncoding RNAs; SNI, spared nerve injury; SNT, spinal nerve transection.