Table 3. Total mean annual cost per patient (Brazilian Reais 2016).

	Annual costs per patient (R$ 2016)
	Mean (SD)	Median [95% CI]	% of total societal costs
Total costs, societal perspective	33.872 (34.807)	25.638 [0–126.789]
Direct costs, societal perspective	27.355 (30.786)	22.786 [0–114.888]	80.8%
Direct costs, payer perspective*	16.793 (21.713)	19.915 [0–42.686]	49.6%
Inpatient care	839 (3.148)	0 [0–9.209]	2.5%
Healthcare consultations	197 (495)	80 [0–1.304]	0.6%
Test and investigations	870 (1.025)	49 [0–2.664]	2.6%
Prescription medicines	1.216 (5.788)	0 [0–6.976]	3.6%
Disease-modifying treatments	13.634 (20.340)	19.820 [0–28.423]	40.3%
Investments, equipment and aids	25 (279)	0 [0–80]	0.08%
Assistance	12 (150)	0 [0–0]	0.04%
Patients’ out-of-pocket costs	7.018 (18.213)	913 [0–82.034]	20.7%
Informal care	3.544 (8.306)	0 [0–30.407]	10.5%
Indirect costs	6.517 (12.204)	0 [0–30.407]	19.2%
Short-term absence	418 (1.551)	0 [0–7.602]	1.2%
Long-term sick-leave 0–12 months	841 (4.253)	0 [0–22.805]	2.5%
Permanent sick-leave/invalidity pension	5.258 (11.507)	0 [0–30.407]	15.5%

*excluding patients’ out-of-pocket costs and informal care