Figure 3.
Brain regions reflecting the different influences of the cTBS condition on the linear relationship between brain activation and stimulus strength, modeled at the SPM first-level analysis as contrast [3 1 1 3] for the nociceptive stimuli at CO2 concentrations of 35, 50, 65, and 80% vol/vol. The results of a factorial 2 × 3 ANOVA testing the influence of the factors “measurement” (baseline, post-cTBS) and “condition” (cTBS condition: M1 verum, S2 verum, and sham) on the linear relationship between stimulus strength and associated brain activations addressed in the first-level analysis are shown as a glass brain representation (left) and superimposed on axial slices of the canonical MR template implemented in SPM12 (right). The significance at voxel level is color coded from dark red to yellow with increasing F values (Table 2). Activations are shown at a threshold of P < 0.05 (family-wise error-corrected). The figure was created using the SPM12 Matlab toolbox (http://www.fil.ion.ucl.ac.uk/spm/software/spm12/; Wellcome Department of Imaging Neuroscience, London, United Kingdom24,92) and the xjView Matlab toolbox (http://www.alivelearn.net/xjview). ANOVA, analysis of variance; cTBS, continuous theta-burst stimulation.