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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Drug Alcohol Depend. 2018 May 24;189:21–29. doi: 10.1016/j.drugalcdep.2018.04.022

Table 3.

Association between AUDIT-C change scores and change in CD4 and log VL: Results of contrast tests* for comparison of mean changes in CD4 and log Viral Load between a priori- and post hoc- specified change scores.

AUDIT-C change score Predicted change in HIV-related Outcome Difference in change in HIV-related outcome (95% CI) p-value*
ΔA ΔA' ΔY (95% CI) ΔY' (95% CI) ΔY' − ΔY (95% CI)
CD4 Sample
A priori contrasts to test hypothesis
0 −2 18.5 (15.9, 21.2) 22.5 (17.8, 27.1) 4.0 (−1.1, 9.0) 0.12
0 −5 18.5 (15.9, 21.2) 14.1 (7.8, 20.4) −4.2 (−10.7, 2.2) 0.20
−5 −8 14.1 (7.8, 20.4) 5.2 (−6.1, 16.6) −8.8 (−15.0, −2.8) 0.005
Post-hoc contrast tests to assess effects of decreases in drinking
0 +2 18.5 (15.9 – 21.2) 23.3 (18.6, 28.1) −4.9 (−10.1, 0.4) 0.07
0 +5 18.5 (15.9 – 21.2) 20.2 (12.9, 27.6) −1.7 (−9.3, 5.8) 0.66
+5 +8 20.2 (12.9 – 27.6) 16.7 (3.0, 30.5) 3.5 (−3.8, 10.8) 0.35
+8 −8 16.7 (3.0, 30.5) 5.2 (−6.1, 16.6) 11.5 (−6.5, 29.5) 0.21
Viral Load Sample
A priori contrasts to test hypothesis
0 −2 0.05 (0.04, 0.05) 0.03 (0.02, 0.04) −0.02 (−0.03, −0.00) 0.01
0 −5 0.05 (0.04, 0.05) −0.01 (−0.03, 0.01) −0.06 (−0.08, 0.04) <0.0001
−5 −8 −0.01 (−0.03, 0.01) −0.05 (−0.09, −0.01) −0.04 (−0.06, −0.02) 0.0001
Post-hoc contrast tests to assess effects of decreases in drinking
0 +2 0.05 (0.04, 0.05) 0.04 (0.02, 0.5) −0.01 (−0.02, 0.00) 0.07
0 +5 0.05 (0.04, 0.05) 0.01 (−0.00, 0.03) −0.03 (−0.5, −0.02) 0.0002
+5 +8 0.01 (−0.00, 0.03) −0.01 (−0.04, 0.02) −0.02 (−0.04, −0.01) 0.009
+8 −8 −0.01 (−0.04, 0.02) −0.05 (−0.09, −0.01) −0.04 (10.09, −0.01) 0.13

KEY: Above, mean changes in the outcomes (ΔY) associated with an AUDIT-C change score (ΔA) are compared to mean changes in the outcomes ( ΔY') associated with another AUDIT-C change score (ΔA'); negative AUDIT-C change score indicates increased AUDIT-C; positive AUDIT-C change score indicates decreased AUDIT-C

*

p-value for contrast, tested using primary model (Block 2) adjusted for demographics, disease severity at baseline, and days between severity measures.