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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Ann Biomed Eng. 2018 Nov 28;47(2):366–380. doi: 10.1007/s10439-018-02171-3

Table 1:

Common hemostatic regulators synthesized by endothelial cells in response to environmental cues.

Protein Function
Prothrombotic Proteins Von Willebrand Factor (vWF) Large multimeric glycoprotein that binds to platelets and proteins during thrombus formation34
Tissue Factor (TF) Surface protein expressed by activated endothelial cells to initiate coagulation cascade162
Plasminogen activator inhibitor (PAI-1) Inhibitor of tPA12
Antithrombotic Proteins A disintegrin and metalloproteinase with a thrombospondin type I motif, member 10 (ADAMTS-13) Enzyme that cleaves vWF141
Tissue factor pathway inhibitor (TFPI) Major inhibitor of TF, Factor Xa, and thrombin162
Tissue plasminogen activator (tPA) Regulator of fibrinolysis12
Endothelial nitric oxide synthase (eNOS) enzyme that catalyzes the production of nitric oxide which inhibits platelet aggregation161
Activated protein C (APC) Glycoprotein that proteolytically inactivates factor Va and VIIIa to reduce thrombin formation56