. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Ann Biomed Eng. 2018 Nov 28;47(2):366–380. doi: 10.1007/s10439-018-02171-3

Table 1:

Common hemostatic regulators synthesized by endothelial cells in response to environmental cues.

	Protein	Function
Prothrombotic Proteins	Von Willebrand Factor (vWF)	Large multimeric glycoprotein that binds to platelets and proteins during thrombus formation³⁴
	Tissue Factor (TF)	Surface protein expressed by activated endothelial cells to initiate coagulation cascade¹⁶²
	Plasminogen activator inhibitor (PAI-1)	Inhibitor of tPA¹²
Antithrombotic Proteins	A disintegrin and metalloproteinase with a thrombospondin type I motif, member 10 (ADAMTS-13)	Enzyme that cleaves vWF¹⁴¹
	Tissue factor pathway inhibitor (TFPI)	Major inhibitor of TF, Factor Xa, and thrombin¹⁶²
	Tissue plasminogen activator (tPA)	Regulator of fibrinolysis¹²
	Endothelial nitric oxide synthase (eNOS)	enzyme that catalyzes the production of nitric oxide which inhibits platelet aggregation¹⁶¹
	Activated protein C (APC)	Glycoprotein that proteolytically inactivates factor Va and VIIIa to reduce thrombin formation⁵⁶