. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Ann Biomed Eng. 2018 Nov 28;47(2):366–380. doi: 10.1007/s10439-018-02171-3

Table 6:

Summary of the effects of endothelial cell attachment to fibronectin and gelatin on hemostatic regulator molecule expression.

ECM Protein	Substrate Application	Cell type	Molecules tested	Results
Gelatin	Gelatin coat on TCPS	Bovine aortic endothelial cell; human saphenous vein endothelial cell	PGI2, PAI, tPA	Increase in NO and PAI; Decrease in PGI2 compared to TCPS^{7, 53}
	ePTFE with gelatin coat	Human umbilical vein endothelial cell	PGI2, PAI-1, tPA	Increase in PGI2, PAI-1 and t-PA compared to bare¹⁰⁰
	PEG-RGD hydrogel	Porcine aortic valvular endothelial cell	ADAMTS-13, TFPI, tPA, vWF, TF, P-selectin	ADAMTS-13, TFPI, tPA, tPA, vWF, TF, P-selectin all increased compared to TCPS⁶
Fibronectin	Fibronectin coat on TCPS	Bovine aortic; human umbilical vein; human saphenous vein	PGI2, vWF, tPA, PAI-1	Increase in PGI2; decreased vWF compared to TCPS; no significant change in _tPA^{7, 53, 165}
Fibronectin	ePTFE with Fn coat	Human saphenous vein endothelial cell; human umbilical vein endothelial cell	tPA, PGI2, PAI-1	Increase in PGI2 and tPA compared to bare ePTFE; no significant change in PAI-1^{96, 175}