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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: J Mol Neurosci. 2018 Nov 23;67(1):1–15. doi: 10.1007/s12031-018-1194-z

Figure 2.

Figure 2.

Effect of METH on ethanol intake and preference during the conditioning phase. Rats had free access to three bottles containing water, 15% ethanol, and 30% ethanol for five weeks. Ethanol intake and preference were measured during the last two weeks and served as a baseline. Rats were then administered METH (2.5 mg/kg/day) or saline for seven days during the conditioning phase, and ethanol intake (A), preference (B), water intake (C), and body weight (D) were assessed daily. METH significantly decreased ethanol intake as compared to the saline group during Day 1, 3–5 of conditioning. Ethanol preference was decreased following METH in Day 3–6 of conditioning. Water intake was significantly increased in METH treated rats as compared to salin- treated rats during Day 1, 2 and 4 of conditioning. Body weight was not significantly changed following METH during the conditioning phase *p<0.05, **p<0.01, and ****p<0.0001. (n = 7–21).