FIG. 6.

A model illustrating sequential acquisition of genetic lesions. Previous studies have established that IDH1 mutations are the key drivers for gliomagenesis and precede other major genetic alterations such mutations in p53, ATRX, and TERT and co-deletion of chromosome 1p/19q. We discovered the presence of regional chromosomal alterations in at least a subset of LGGs before acquiring the IDH1 mutations, which may represent predisposing conditions for IDH1 mutations and/or be cooperating with the IDH1 mutations in gliomagenesis.