Table IV.
Genetic Diversity of Human Monoclonal Antibodies
| Antibody | Isotype | Reactivity | Gene Family | Germline Homology (Vh/Vl) |
|---|---|---|---|---|
| F860 A2e10 | IgG2, k | gp120-CD4 FLSC | IgHV1–69(*01F or *12F) IgkV1–13*02 |
95.1%/96.1% |
| F860 B1d3 | IgG1, λ | gp41 | --a | -- |
| F860 B2c9 | IgG2, λ | gp41 | -- | -- |
| F860 B2e12 | IgG1, λ | gp41 | -- | -- |
| F861 A3h3 | IgG1,k | gp120-CD4 FLSC | -- | -- |
| F861 A7f10 | IgG3,λ | gp120-CD4 FLSC | IgHV1–69(*01F or *12F) IgLV5–45*02F |
99.6/99.0 |
| F862 A1f6 | IgG1, λ | gp120-CD4 FLSC | IgHV1–69*05F IgLV3–9*01F | 95.5/100 |
| F862 A3b11 | IgG2,λ λ | gp41 | IgHV4–34*01F IgLV2–23*02F |
96.8/99.7 |
| F862 A5a7 | IgG1, λ | gp120-CD4 FLSC | IgHV3–30(*04F or *03F) IgLV2–23*02F |
100/100 |
| F862 A5d2 | IgG2, λ | gp120-CD4 FLSC | -- | -- |
| F862 B4h11 | IgG1, λ | gp120-CD4 FLSC | -- | -- |
| F862 B12h6 | IgA, λ | gp120-CD4 FLSC | IgHV4–30-2*04F IgLV1–47*01F |
91.1/98.3 |
| F878 A2a9 | IgG1, λ | gp120 | IgHV1–69*01F IgLV3–19*01F |
94.1/97.1 |
| F878 B2e12 | IgG1, k | gp120, gp120-CD4 FLSC | IgHV3–33(*01F or *06F) IgKV1–17*03F |
91.5/96.7 |
a
-- = Antibodies not characterized