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. Author manuscript; available in PMC: 2019 Mar 6.
Published in final edited form as: Mol Neurobiol. 2018 May 24;56(2):833–843. doi: 10.1007/s12035-018-1123-8

Figure 2: Derivation of functional tanycytes from ES and iPS cells:

Figure 2:

The derivation of tanycytes from the ES and iPS cells has not yet been attempted. We propose that the lineage commitment and the directed differentiation of ES and iPS cells into tanycytes can be achieved in vitro. A simplified version of the directed differentiation as depicted in our scheme has the potential to generate an unlimited source and supply of tanycytes. The ES and iPS cell-derived tanycytes can be successfully used to study their normal physiological function using 3D organoids, as well as to develop disease in a dish model, perform genome editing to decipher functional genomics, neuroepigenomics, proteomics, high throughput screening of chemical libraries for novel drug discovery as well as transplantation and in vivo transdifferentiation studies to develop tanycyte-based regenerative therapies to treat type 2 diabetes and AD.