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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Arch Toxicol. 2018 Oct 15;93(1):163–178. doi: 10.1007/s00204-018-2331-8

Figure 10: MT treatment inhibits APAP-induced RIP3 kinase activation and RIP3 kinase deficiency promotes caspase 3 activity.

Figure 10:

Mice were treated with 300 mg/kg APAP, followed by 20 mg/kg MT or saline 1.5 h later. (A) Western blot for RIP3 kinase protein levels 24h after APAP and (B) densitometric quantitation of western blot. (C) Western blot showing caspase cleavage and (D) caspase 3 activity in liver homogenates. Bars represent means ± SEM for n = 3 mice per group. *p<0.05 vs. APAP (B) and *p<0.05 vs. Ctrl. (D).