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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Arch Toxicol. 2018 Oct 15;93(1):163–178. doi: 10.1007/s00204-018-2331-8

Figure 5: Pan-caspase inhibitor prevented caspase activation in MT treated mice.

Figure 5:

Mice were treated with 300 mg/kg APAP, followed by 20 mg/kg MT or saline 1.5 h later, with or without 10 mg/kg ZVD-fmk or its vehicle 2h later. (A) Caspase-3 activity in liver homogenate. (B) Caspase-3 cleavage analyzed with western blotting. Bars represent means ± SEM for n = 4 mice per group. *p<0.05 vs. APAP. #p<0.05 vs. APAP+MT.