Skip to main content
. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Arch Toxicol. 2018 Oct 15;93(1):163–178. doi: 10.1007/s00204-018-2331-8

Figure 6: Pan-caspase inhibitor further protected against late phase of APAP hepatotoxicity.

Figure 6:

Mice were treated with 300 mg/kg APAP, followed by 20 mg/kg MT or saline 1.5 h later, with or without 10 mg/kg ZVD-fmk or its vehicle 2h later. (A) Plasma levels of ALT. (B) H&E stained liver sections (200x). (C) TUNEL stained liver sections (100x). Bars represent means ± SEM for n = 4 mice per group. *p<0.05 vs. Ctrl. #p<0.05 vs. APAP. $p<0.05 vs. APAP+MT.